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1994-10-25
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Document 3025
DOCN M94A3025
TI Kaposi's sarcoma (KS) epidemiology in a public hospital district,
Houston, TX.
DT 9412
AU Shandera WX; Wilson J; Ben Taub Hospital, Baylor College of Medicine,
Houston, TX 77030.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):170 (abstract no. PB0105). Unique
Identifier : AIDSLINE ICA10/94369550
AB OBJECTIVE: To assess KS epidemiology among patients treated in Harris
County Hospital District. METHODS: A retrospective review of demographic
and clinical variables, among all AIDS patients with KS, treated between
1987 and 1994, identified by coding and surveillance data. RESULTS: Of
286 possible cases, 225 records were available by 2/25/94 (6-10% of all
pts). Study group included 223 men, was largely white (63%) and
homosexual (81%). Median age at KS diagnosis was 34, at HIV diagnosis 32
(interval median, 14 months). KS was AIDS-defining dx in 44%. Median CD4
count at diagnosis was 32/mm3. KS was disseminated at dx in 43%, limited
in 36%. Recent cases (after 1/91) were more often nonwhite (p = 0.03),
associated with nonsexual HIV transmission (p = 0.02) and had oral
lesions (p 0.05). Best clinical responses were with intralesional
interferon (79% complete or partial responses), vincristine/vinblastine
(55%), or adriamycin/vinblastine/bleomycin (48%). DISCUSSION AND
CONCLUSIONS: KS occurs in 6-10% of all AIDS patients treated in our
public hospital district, is often AIDS-defining, and presents with CD4
lymphopenia. Its epidemiology has changed with time. Certain
chemotherapy regimens are associated with good responses.
DE Acquired Immunodeficiency Syndrome/DRUG THERAPY/EPIDEMIOLOGY/
IMMUNOLOGY Adult Antineoplastic Agents, Combined/THERAPEUTIC USE
Cross-Sectional Studies Female Homosexuality Hospitals, Public
Hospitals, Urban Human HIV Infections/DRUG
THERAPY/*EPIDEMIOLOGY/IMMUNOLOGY Incidence Leukocyte Count Male
Population Surveillance Retrospective Studies Sarcoma, Kaposi's/DRUG
THERAPY/*EPIDEMIOLOGY/IMMUNOLOGY Skin Neoplasms/DRUG
THERAPY/*EPIDEMIOLOGY/IMMUNOLOGY Texas/EPIDEMIOLOGY T4
Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).